The diffraction data on the crystal of VWF A1/BT‐100 RNA was collected at SSRF beam line 17U1 and processed to 2.09 Angstrom resolution in space group P21212. 20 Similar protein purification, crystallization, and data collection method was used. The VWF A1 domain has been previously purified and cocrystallized with a DNA aptamer ARC1172. 2.3 Cocrystallization of BT100 with VWF A1 domain.